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Post by span870 on Jul 15, 2015 7:29:24 GMT -5
Just wanted to give everyone a heads up. I had to put one of my beagles down yesterday. Dog was completely fine two days ago. Running around the yard, playing in the kiddie pool we have for them, eating and drinking fine. I put their flea med on them, k9 advantix ii, and went to bed. Woke up the next morning and he was completely paralized except for his head. We rushed him to the vet, ran a battery of tests. Blood work came back fine, sugar levels fine. No internal damage and no spinal damage. Eyes were reacting fine so that took out a stroke.
Did some research about the meds that I have been worrying about for awhile. The meds contains a dose of permetherin of 44% of total make up of drug. Human dosage is .05% and approved for clothing only. There have been alot of issues with this drug. Found out by talking to a friend of one of my buddies that is a vet that this is a known problem that vets will not acknowledge with bayer products because most are under a contract and pet paid a commission to sell their products. He flat out refuses to sell the product, letting it expire on his shelves before be will sell it. The vet I took my dog to would not confirm, nor deny that this is an issue or would she deny it was what caused this. If you are going to use a permetherin based product do not put it on overnight. Put it on when you can watch them and keep a bottle of Dawn dishwashing soap handy. At the first sign of issue, wash the dog completely with the detergent and get the med off.
I know people will say, I put it on and never had an issue. Yeah so did I. What I found out is that with permetherin based products the dogs resistance to the drug interaction wears down over time and the more times you out it on the greater the chance of reaction. Just be careful if you do. We lost my wife's house beagle and a great buddy to a horrible death.
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Post by featherduster on Jul 15, 2015 7:43:06 GMT -5
Sorry for your loss and thank you for the heads up on the Advantixll.
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Post by nfalls116 on Jul 15, 2015 7:50:10 GMT -5
I usually just use ivermectin for worms and it seems to keep them going strong and flea and tick free And it's hard cause we usually only lose our favorite ones I am dreading the day our current dog passes my little one is getting more and more attached
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Post by Woody Williams on Jul 15, 2015 8:30:20 GMT -5
Sorry to hear that Shane. I know Permethrin is very toxic for cats, but I thought it was ok for dogs and other animals..
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Post by span870 on Jul 15, 2015 9:02:40 GMT -5
Sorry to hear that Shane. I know Permethrin is very toxic for cats, but I thought it was ok for dogs and other animals.. Thought to be. If you do some searching what you find is eye opening. Found out it is a huge no no for collie type dogs. Also so many reports of allergic reactions. Dogs with white fur are more susceptible to toxicity. Thinking the skin is more transparent. Very few studies have actually been done on it topically. Most were internal. Zero long term studies. What I've gotten from talking to several vets that didn't have a hand in treating mine is with a short lifespan on dogs, companies see no use in a study. I've had many buddies losing young dogs to cancer and kidney failure that use these products that it makes you wonder. These are healthy dogs in tip top condition. Better condition than most keep their dogs. Top of the line food and excersize more than most. Very little actual studies on reports. Google search advantix II reviews and side effects. Bayer has begun reimbursing customers vet bills for reaction to the drug. Of course its, you overdosed or applied it wrong. Again vets have a financial stake in selling them. What I've noticed over several days though is very few push permetherin based but will sell it. Actually of the four vets I've dealt with, NONE suggested it, one telling me it IS toxic.
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Post by chubwub on Jul 15, 2015 10:38:21 GMT -5
First of all I want to say that I am very sorry for your loss. I was not there to see your dog but I will say that a complete paralysis with no other symptoms (unless you have have left the other ones out) is highly unusual for permethrin toxicity. Usually what you will see in severe cases is muscle tremors, vomiting, diarrhea, hyper-salivation and seizures and this occurs mostly in a canine when the dog does something incredibly stupid like eat the entire tube of flea medication. I would also expect to see some kind of skin reaction at the site where you placed the medication. Most of the time they just get a skin reaction, as absorbing enough pemerthrin through the skin to cause a systemic reaction is quite difficult unless the dog has literally been bathed in a vat of the stuff.It is also unusual that your dog did not recover as most animals will recover from pemerthrin toxicity with veterinary care.
I hope the vet has more answers for you that are a bit more concrete, as I said before, a sudden, complete paralysis without any other symptoms and clean bloodwork is highly unusual. It could have been something as simple as a pinched nerve in just the right place, or something like the tick medication not working and your dog contracting Lyme disease, which can cause sudden paralysis. It could have easily been one of the other 2 actives ingredients in the medication or one one the inert ingredients. Perhaps she rolled in some water and the medication washed off and then she ingested the water that she rolled in.
There is a lot of natural alarmist hype and misinformation regarding permethrin not being tested that is on par with the vaccines causing autism BS. Permethrin has been used for just about 100 years in a variety of applications and has been tested quite thoroughly on everything from monkeys to rats for oral and dermal applications. They even know the rate of absorption through the skin for each species...rat absorbs the fastest. The toxicity effects of pemerthrin are well documented as well. As for long term studies, you must keep in mind that conducting a 1-2 year study on an animal that only lives on average for 12-14 years is a very long study in terms of lifespan for that animal. It is equivalent to conducting a decade long study for a human being. These vets are correct, there is no use in conducting a decade long toxicity study in an animal that only lives for a decade when you can get all the information needed in 1-2 years in a true lifespan toxicity study on rats which have many of the same physiological characteristics of canines.
Trust me when I say that if there was a known issue with the product killing pets, ethical vets would be the first to speak up about it, even with a financial stake involved. There are plenty of other products to sell and services to offer in which they can make a profit. It does not matter if you are under contract to sell the product or not, there are policies in place to protect doctors and vets who are whistle blowers. A lot of vets will not recommend Advantix simply it because it doesn't work worth a darn.
Once again I hope that you can find some concrete answers. I do not like that the vet simply remained silent and allowed you to think that Advantix was the culprit instead of having a heart to heart with you about how difficult and challenging this diagnosis was and that he/she probably did not have a satisfactory answer for what happened.
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Post by chubwub on Jul 15, 2015 10:54:52 GMT -5
I also wanted to add this link about Fibrocartligenous embolism. www.robinsonvet.com/documents/Fibrocartilagenoussynd.pdfSometimes without advanced spinal imaging techniques such as a MRI or CT scan along with myelogram, this condition will frequently not be noticed on regular spinal radiography exams. The blood-work will also come back normal on the dog. What kind of spinal imaging did your vet do?
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Post by span870 on Jul 15, 2015 13:03:38 GMT -5
First I mis spoke. I was using layman's terms that he was paralized. What the vet said was comostose.
I won't argue with you on effects and causes on animals on chemicals. You have way more knowledge than me.
As far as vets not selling permetherin based meds, I agree they shouldn't. The four I talked to don't. Three won't recommend and the fourth outright will tell you its poison. They are in a contract with Bayer. They must sell the products or face fines. It's easier to let the product expire on the shelf than sell it.
What I can say is there are thousands of complaints about advantix II. Very few about most others unless they are permetherin based. The EPA demanded that bayer do more testing on the short, long, and side effects on this particular one. One of the side effects of permetherin toxicity is temporary paralysis. Again these are my words as far as paralysis, comostose is what the vet used.
As far as any testing after the original vet, we were on our way to Louisville to the vet hospital there when the dog had no less than four seizures before we could get there. We had to stop at a vet before we got there. There was no chance for a pinched nerve. The dog layed down when he went to bed beside me and never moved after. I've seen enough animals poisoned to know how an animal reacts after it happens.
I am no way saying this will happen to every dog. Just be careful and do your research. There are thousands of complaints you can find that isn't just me. As far as the studies Bayer put out themselves, I trust them as much as I do the Brady Campaign on gun violence.
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Post by span870 on Jul 15, 2015 13:07:27 GMT -5
As far as whether advantix works, I have yet to find anything that worked better. There isnt any other product out there that will repel fleas, ticks, and mosquitos. My dogs are ran year round and I have never found a live tick or flea on them. But it is poison. You want to take the chance, have at it. As for me, never again. They don't recommend it because of the risk. Again to one that told me its flat out poison to dogs.
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Post by chubwub on Jul 15, 2015 14:01:42 GMT -5
How much did your dog weigh?
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Post by span870 on Jul 15, 2015 15:39:21 GMT -5
35-40 pounds
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Post by chubwub on Jul 15, 2015 16:19:02 GMT -5
Very odd. They will absorb some through the skin, but only about 1%, it is very hard to get drugs absorbed through the skin. Dogs start showing mild toxicity with oral ingestion at 50mg/kg, or in your case 795mg needs to be ingested orally. She would have to eat an entire tube of the 100lb dose (1.76 grams or 1,076mg) Advantix to start showing symptoms. Most vet do not like Advantix because of the toxicity to cats, which is well documented but has very few effects on most dogs over 20 lbs.
I still strongly feel that something else is going on. I would examine your environment very carefully. Were the seizures the only symptom or were their others? Just having seizures can be difficult to diagnose.
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Post by greghopper on Jul 15, 2015 17:47:38 GMT -5
Was this "Tick" medicine or flea medicine
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Post by span870 on Jul 15, 2015 18:21:07 GMT -5
Was this "Tick" medicine or flea medicine It's for flea, tick, and mosquito's. Reason I used it was the mosquito repellent because my beagles are outside.
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Post by greghopper on Jul 15, 2015 18:25:08 GMT -5
K.... Seen the title of thread and was wondering !!!
I Got 2 elk hounds and that's the brand I use on them for fleas...
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Post by span870 on Jul 15, 2015 19:05:50 GMT -5
Very odd. They will absorb some through the skin, but only about 1%, it is very hard to get drugs absorbed through the skin. Dogs start showing mild toxicity with oral ingestion at 50mg/kg, or in your case 795mg needs to be ingested orally. She would have to eat an entire tube of the 100lb dose (1.76 grams or 1,076mg) Advantix to start showing symptoms. Most vet do not like Advantix because of the toxicity to cats, which is well documented but has very few effects on most dogs over 20 lbs. I still strongly feel that something else is going on. I would examine your environment very carefully. Were the seizures the only symptom or were their others? Just having seizures can be difficult to diagnose. Which is it? First you say vets don't recommend it because it doesn't work than you say the dont recommend because its toxic to cats. I've had 4 not recommend. Three wouldn't say why and the fourth flat out said its toxic to dogs. Anyone that knows my farm, knows there is zero chance to get into anything poison. I watched a cat die that ate a poisoned mouse. Horrible thing. I don't even have mouse poison or insecticides anywhere they can get to them. You can push all the "facts" you want but it doesn't change the fact that you have a healthy dog, place meds on it, the next morning you wake up and he is in a comatose state. After first checkup the vet wanted to know what he could have gotten into because she was leaning towards poison. Again why is the EPA pushing for more regulations and oversight into spot on treatments, especially this one, if there isn't a problem. The fact is the rates of complaints to the EPA over doubled in a 5 year span. Anywhere from rashes, burns, muscle spasms, seizures, and death. I won't comment again to you on this because I don't want to argue it. I'm not saying don't use it. I personally never will. If you are, put it on that you can watch the dog for no less than 12 hours, keep a bottle of Dawn dishwashing detergent handy, and at the first sign wash the dog to stop the absorption into the skin. I won't take away from it. The stuff works better than anything else. Just because you use it and have no issues it doesn't mean you won't. Every time you put it on it increases to chance of an adverse reaction. A simple Google search will give you all the info you need. Some scientific, some just regular ol people telling bad tales.
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Post by duff on Jul 15, 2015 19:25:00 GMT -5
Sorry to hear that Shane. I know how you like your little hounds.
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Post by greghopper on Jul 15, 2015 21:12:46 GMT -5
Shane.... can you post a pic or link to the type of stuff you used?
thanks...
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Post by span870 on Jul 15, 2015 21:41:56 GMT -5
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Post by esshup on Jul 17, 2015 11:48:49 GMT -5
Regarding poison, it's all in the dosage.
I believe that doctors prescribe warfarin to humans, but it's also used as rat poison.....
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