CWD TSE PRIONS, LIONS AND TIGERS AND BEARS OH MY !
Oct 14, 2016 21:32:47 GMT -5
tenring and nfalls116 like this
Post by flounder9 on Oct 14, 2016 21:32:47 GMT -5
SATURDAY, OCTOBER 08, 2016
Modeled Impacts of Chronic Wasting Disease on White-Tailed Deer in a Semi-Arid Environment
chronic-wasting-disease.blogspot.com/2016/10/modeled-impacts-of-chronic-wasting.html
SUNDAY, OCTOBER 02, 2016
What is the risk of a cervid TSE being introduced from Norway into Great Britain? Qualitative Risk Assessment September 2016
chronic-wasting-disease.blogspot.com/2016/10/what-is-risk-of-cervid-tse-being.html
Title: Pathological features of chronic wasting disease in reindeer and demonstration of horizontal transmission Author
item Moore, Sarah item Kunkle, Robert item West greenlee, Mary item Nicholson, Eric item Richt, Juergen item Hamir, Amirali item Waters, Wade item Greenlee, Justin
Submitted to: Emerging Infectious Diseases Publication Type: Peer reviewed journal Publication Acceptance Date: 8/29/2016 Publication Date: N/A Citation:
Interpretive Summary: Chronic wasting disease (CWD) is a fatal neurodegenerative disease that occurs in farmed and wild cervids (deer and elk) of North America and was recently diagnosed in a single free-ranging reindeer (Rangifer tarandus tarandus) in Norway. CWD is a transmissible spongiform encephalopathy (TSE) that is caused by infectious proteins called prions that are resistant to various methods of decontamination and environmental degradation. Little is known about the susceptibility of or potential for transmission amongst reindeer. In this experiment, we tested the susceptibility of reindeer to CWD from various sources (elk, mule deer, or white-tailed deer) after intracranial inoculation and tested the potential for infected reindeer to transmit to non-inoculated animals by co-housing or housing in adjacent pens. Reindeer were susceptible to CWD from elk, mule deer, or white-tailed deer sources after experimental inoculation. Most importantly, non-inoculated reindeer that were co-housed with infected reindeer or housed in pens adjacent to infected reindeer but without the potential for nose-to-nose contact also developed evidence of CWD infection. This is a major new finding that may have a great impact on the recently diagnosed case of CWD in the only remaining free-ranging reindeer population in Europe as our findings imply that horizontal transmission to other reindeer within that herd has already occurred. Further, this information will help regulatory and wildlife officials developing plans to reduce or eliminate CWD and cervid farmers that want to ensure that their herd remains CWD-free, but were previously unsure of the potential for reindeer to transmit CWD.
Technical Abstract: Chronic wasting disease (CWD) is a naturally-occurring, fatal prion disease of cervids. Reindeer (Rangifer tarandus tarandus) are susceptible to CWD following oral challenge, and CWD was recently reported in a free-ranging reindeer of Norway. Potential contact between CWD-affected cervids and Rangifer species that are free-ranging or co-housed on farms presents a potential risk of CWD transmission. The aims of this study were to 1) investigate the transmission of CWD from white-tailed deer (Odocoileus virginianus; CWDwtd), mule deer (Odocoileus hemionus; CWDmd), or elk (Cervus elaphus nelsoni; CWDelk) to reindeer via the intracranial route, and 2) to assess for direct and indirect horizontal transmission to non-inoculated sentinels. Three groups of 5 reindeer fawns were challenged intracranially with CWDwtd, CWDmd, or CWDelk. Two years after challenge of inoculated reindeer, non-inoculated negative control reindeer were introduced into the same pen as the CWDwtd inoculated reindeer (direct contact; n=4) or into a pen adjacent to the CWDmd inoculated reindeer (indirect contact; n=2). Experimentally inoculated reindeer were allowed to develop clinical disease. At death/euthanasia a complete necropsy examination was performed, including immunohistochemical testing of tissues for disease-associated CWD prion protein (PrPcwd). Intracranially challenged reindeer developed clinical disease from 21 months post-inoculation (months PI). PrPcwd was detected in 5 out of 6 sentinel reindeer although only 2 out of 6 developed clinical disease during the study period (< 57 months PI). We have shown that reindeer are susceptible to CWD from various cervid sources and can transmit CWD to naïve reindeer both directly and indirectly.
Monday, September 05, 2016
*** Pathological features of chronic wasting disease in reindeer and demonstration of horizontal transmission Major Findings for Norway ***
www.ars.usda.gov/research/publications/publication/?seqNo115=328261
Monday, September 05, 2016
Pathological features of chronic wasting disease in reindeer and demonstration of horizontal transmission Major Findings for Norway
chronic-wasting-disease.blogspot.com/2016/09/pathological-features-of-chronic.html
Thursday, September 22, 2016
NORWAY DETECTS 5TH CASE OF CHRONIC WASTING DISEASE CWD TSE PRION Skrantesjuke
chronic-wasting-disease.blogspot.com/2016/09/norway-detects-5th-case-of-chronic.html
Wednesday, September 7, 2016
*** An assessment of the long-term persistence of prion infectivity in aquatic environments
transmissiblespongiformencephalopathy.blogspot.com/2016/09/an-assessment-of-long-term-persistence.html
Friday, September 02, 2016
*** Chronic Wasting Disease Drives Population Decline of White-Tailed Deer
chronic-wasting-disease.blogspot.com/2016/09/chronic-wasting-disease-drives.html
Monday, August 29, 2016
*** NWHC USGS CHRONIC WASTING DISEASE CWD TSE PRION UPDATE
chronic-wasting-disease.blogspot.com/2016/08/nwhc-usgs-chronic-wasting-disease-cwd.html
Thursday, August 18, 2016
*** PROCEEDINGS ONE HUNDRED AND Nineteenth ANNUAL MEETING of the USAHA BSE, CWD, SCRAPIE, PORCINE TSE PRION October 22 28, 2015 ***
chronic-wasting-disease.blogspot.com/2016/08/proceedings-one-hundred-and-nineteenth.html
Monday, May 02, 2016
*** Zoonotic Potential of CWD Prions: An Update Prion 2016 Tokyo
chronic-wasting-disease.blogspot.com/2016/05/zoonotic-potential-of-cwd-prions-update.html
Saturday, April 23, 2016
*** SCRAPIE WS-01: Prion diseases in animals and zoonotic potential 2016
scrapie-usa.blogspot.com/2016/04/scrapie-ws-01-prion-diseases-in-animals.html
Monday, August 29, 2016
*** NWHC USGS CHRONIC WASTING DISEASE CWD TSE PRION UPDATE
chronic-wasting-disease.blogspot.com/2016/08/nwhc-usgs-chronic-wasting-disease-cwd.html
chronic-wasting-disease.blogspot.com/
Sunday, August 28, 2016
*** TSE PRIONS AKA MAD COW TYPE DISEASE, LIONS AND TIGERS AND BEARS, OH MY! ***
transmissiblespongiformencephalopathy.blogspot.com/2016/08/transmissible-spongiform-encephalopathy.html
transmissiblespongiformencephalopathy.blogspot.com/
TSS
Modeled Impacts of Chronic Wasting Disease on White-Tailed Deer in a Semi-Arid Environment
chronic-wasting-disease.blogspot.com/2016/10/modeled-impacts-of-chronic-wasting.html
SUNDAY, OCTOBER 02, 2016
What is the risk of a cervid TSE being introduced from Norway into Great Britain? Qualitative Risk Assessment September 2016
chronic-wasting-disease.blogspot.com/2016/10/what-is-risk-of-cervid-tse-being.html
Title: Pathological features of chronic wasting disease in reindeer and demonstration of horizontal transmission Author
item Moore, Sarah item Kunkle, Robert item West greenlee, Mary item Nicholson, Eric item Richt, Juergen item Hamir, Amirali item Waters, Wade item Greenlee, Justin
Submitted to: Emerging Infectious Diseases Publication Type: Peer reviewed journal Publication Acceptance Date: 8/29/2016 Publication Date: N/A Citation:
Interpretive Summary: Chronic wasting disease (CWD) is a fatal neurodegenerative disease that occurs in farmed and wild cervids (deer and elk) of North America and was recently diagnosed in a single free-ranging reindeer (Rangifer tarandus tarandus) in Norway. CWD is a transmissible spongiform encephalopathy (TSE) that is caused by infectious proteins called prions that are resistant to various methods of decontamination and environmental degradation. Little is known about the susceptibility of or potential for transmission amongst reindeer. In this experiment, we tested the susceptibility of reindeer to CWD from various sources (elk, mule deer, or white-tailed deer) after intracranial inoculation and tested the potential for infected reindeer to transmit to non-inoculated animals by co-housing or housing in adjacent pens. Reindeer were susceptible to CWD from elk, mule deer, or white-tailed deer sources after experimental inoculation. Most importantly, non-inoculated reindeer that were co-housed with infected reindeer or housed in pens adjacent to infected reindeer but without the potential for nose-to-nose contact also developed evidence of CWD infection. This is a major new finding that may have a great impact on the recently diagnosed case of CWD in the only remaining free-ranging reindeer population in Europe as our findings imply that horizontal transmission to other reindeer within that herd has already occurred. Further, this information will help regulatory and wildlife officials developing plans to reduce or eliminate CWD and cervid farmers that want to ensure that their herd remains CWD-free, but were previously unsure of the potential for reindeer to transmit CWD.
Technical Abstract: Chronic wasting disease (CWD) is a naturally-occurring, fatal prion disease of cervids. Reindeer (Rangifer tarandus tarandus) are susceptible to CWD following oral challenge, and CWD was recently reported in a free-ranging reindeer of Norway. Potential contact between CWD-affected cervids and Rangifer species that are free-ranging or co-housed on farms presents a potential risk of CWD transmission. The aims of this study were to 1) investigate the transmission of CWD from white-tailed deer (Odocoileus virginianus; CWDwtd), mule deer (Odocoileus hemionus; CWDmd), or elk (Cervus elaphus nelsoni; CWDelk) to reindeer via the intracranial route, and 2) to assess for direct and indirect horizontal transmission to non-inoculated sentinels. Three groups of 5 reindeer fawns were challenged intracranially with CWDwtd, CWDmd, or CWDelk. Two years after challenge of inoculated reindeer, non-inoculated negative control reindeer were introduced into the same pen as the CWDwtd inoculated reindeer (direct contact; n=4) or into a pen adjacent to the CWDmd inoculated reindeer (indirect contact; n=2). Experimentally inoculated reindeer were allowed to develop clinical disease. At death/euthanasia a complete necropsy examination was performed, including immunohistochemical testing of tissues for disease-associated CWD prion protein (PrPcwd). Intracranially challenged reindeer developed clinical disease from 21 months post-inoculation (months PI). PrPcwd was detected in 5 out of 6 sentinel reindeer although only 2 out of 6 developed clinical disease during the study period (< 57 months PI). We have shown that reindeer are susceptible to CWD from various cervid sources and can transmit CWD to naïve reindeer both directly and indirectly.
Monday, September 05, 2016
*** Pathological features of chronic wasting disease in reindeer and demonstration of horizontal transmission Major Findings for Norway ***
www.ars.usda.gov/research/publications/publication/?seqNo115=328261
Monday, September 05, 2016
Pathological features of chronic wasting disease in reindeer and demonstration of horizontal transmission Major Findings for Norway
chronic-wasting-disease.blogspot.com/2016/09/pathological-features-of-chronic.html
Thursday, September 22, 2016
NORWAY DETECTS 5TH CASE OF CHRONIC WASTING DISEASE CWD TSE PRION Skrantesjuke
chronic-wasting-disease.blogspot.com/2016/09/norway-detects-5th-case-of-chronic.html
Wednesday, September 7, 2016
*** An assessment of the long-term persistence of prion infectivity in aquatic environments
transmissiblespongiformencephalopathy.blogspot.com/2016/09/an-assessment-of-long-term-persistence.html
Friday, September 02, 2016
*** Chronic Wasting Disease Drives Population Decline of White-Tailed Deer
chronic-wasting-disease.blogspot.com/2016/09/chronic-wasting-disease-drives.html
Monday, August 29, 2016
*** NWHC USGS CHRONIC WASTING DISEASE CWD TSE PRION UPDATE
chronic-wasting-disease.blogspot.com/2016/08/nwhc-usgs-chronic-wasting-disease-cwd.html
Thursday, August 18, 2016
*** PROCEEDINGS ONE HUNDRED AND Nineteenth ANNUAL MEETING of the USAHA BSE, CWD, SCRAPIE, PORCINE TSE PRION October 22 28, 2015 ***
chronic-wasting-disease.blogspot.com/2016/08/proceedings-one-hundred-and-nineteenth.html
Monday, May 02, 2016
*** Zoonotic Potential of CWD Prions: An Update Prion 2016 Tokyo
chronic-wasting-disease.blogspot.com/2016/05/zoonotic-potential-of-cwd-prions-update.html
Saturday, April 23, 2016
*** SCRAPIE WS-01: Prion diseases in animals and zoonotic potential 2016
scrapie-usa.blogspot.com/2016/04/scrapie-ws-01-prion-diseases-in-animals.html
Monday, August 29, 2016
*** NWHC USGS CHRONIC WASTING DISEASE CWD TSE PRION UPDATE
chronic-wasting-disease.blogspot.com/2016/08/nwhc-usgs-chronic-wasting-disease-cwd.html
chronic-wasting-disease.blogspot.com/
Sunday, August 28, 2016
*** TSE PRIONS AKA MAD COW TYPE DISEASE, LIONS AND TIGERS AND BEARS, OH MY! ***
transmissiblespongiformencephalopathy.blogspot.com/2016/08/transmissible-spongiform-encephalopathy.html
transmissiblespongiformencephalopathy.blogspot.com/
TSS